Adjective
1. resistant to authority or control;
"as refractory as a mule"2. not responding to treatment;
"a stubborn infection""a refractory case of acne"3. marked by stubborn resistance to and defiant of authority or guidance;
"a recalcitrant teenager""everything revolves around a refractory individual genius"4. stubbornly resistant to authority or control;
"a fractious animal that would not submit to the harness""a refractory child"