A person with a physical disability or a serious permanent injury is sometimes referred to as a cripple .

If someone is crippled by an injury, it is so serious that they can never move their body properly again.

If you describe someone as an emotional cripple, you mean that they have a particular psychological or emotional problem which prevents them from living a normal life.

If something cripples a person, it causes them severe psychological or emotional problems.

To cripple a machine, organization, or system means to damage it severely or prevent it from working properly.